Animals of the Isalo are typical of the climate, the vegetation and the geomorphology of the Park. These are, for a very large majority, endemic species. 77 species of birds live in Isalo including Robin of Benson or Pseudocosyphus bensoni, an endemic species of Madagascar that is highly protected. There is also 14 species of diurnal and nocturnal including lemurs 7 introduced and 7 endemic to the region. Reptiles, amphibians, carnivores, Insectivores and rodents complete the list.
The flora of Isalo National Park is also unique in the world, many plants are endemic to Madagascar such as Pachypodium rosulatum, family Apocynaceae, Catharantus ovalis, which is a medicinal plant that found anywhere elsewhere in the world. The Savannah of the Isalo is colonized by typical Palm trees of this region : Bismarckia nobilis, “Satrana” hence the name of the hotel, fire resistant.